Monotone increasing
Description: binary, monotone increasing variables with no missing values (ex: diagnosis)
afib.dx
Short description: Atrial Fibrillation as a diagnosed condition
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 2+ outpatient dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx, first ED dx, or second outpatient dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
AFib-Dx Notes: Includes atrial fibrillation and atrial flutter.
amputation.dxpx
Short description: Lower extremity non-traumatic amputation as an event on or prior to the index date.
Baseline definition: Date of the px or dx code that is closest to the index date but must be prior to or on the index date. Consider the date of all inpatient dx, ED dx, or px codes from 01/01/2009 up to and including the index date.
Follow-up definition: Date of the earliest discharge inpatient dx (need not be principal diagnosis), first ED dx (need not be primary ED diagnosis) or px after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Amputation-Px,
Amputation-Dx Notes: Only lower extremity non-traumatic amputations are included.
anemia.dx
Short description: Selected anemias as a diagnosed condition
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 2+ outpatient dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx, first ED dx, or second outpatient dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Anemia-Dx
anxiety.dx
Short description: Anxiety as a diagnosed condition
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 1+ outpatient dx code in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx, first ED dx, or first outpatient dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Anxiety-Dx
arrythmia.dx
Short description: Cardiac arrythmias (excluding Atrial Fibrillation and Atrial Flutter) as a diagnosed condition
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 2+ outpatient dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx, first ED dx, or second outpatient dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Arrythmia-Dx
ascvd.dxpx.max
Short description: Atherosclerotic CV Disease as time-dependent covariate (high sensitivity, “Max”).
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED code, 1+ px, or second outpatient diagnosis in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: indicator of 1+ discharge inpatient dx, 1+ ED code, 1+ px, or second outpatient diagnosis after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
MI-Acute-Dx,
CVA-EMB-Dx,
CABG-Stent-Px,
CeVD-Px,
PVD-Px,
CAD-Dx,
CVA-HEM-Dx,
CeVD-Dx,
PVD-Dx Notes: Also used as a subgroup variable.
ascvd.dxpx.ppv
Short description: Atherosclerotic CV Disease as time-dependent covariate (high positive predictive value; PPV).
Baseline definition: indicator of 1+ principal discharge inpatient dx, 1+ primary ED code, or 1+ px, in the 2 years strictly prior to and including the patient’s index date
Follow-up definition: date of the first principal discharge inpatient dx, first primary ED dx, or first px (whichever of the first inpatient dx, first ED dx, or first px occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
MI-Acute-Dx,
CVA-EMB-Dx,
CABG-Stent-Px,
CeVD-Px,
PVD-Px Notes: Also used as a subgroup variable.
asthma.dx
Short description: Asthma as a diagnosed condition
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 2+ outpatient dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx, first ED dx, or second outpatient dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Asthma-Dx
bariatric.px
Short description: Metabolic Bariatric Surgery procedure as time-dependent covariate
Baseline definition: indicator of 1+ px from 1/1/2009 until strictly prior to and including the patient’s index date
Follow-up definition: date of the first px after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Bariatric-Px
bipolar.dx
Short description: Bipolar affective disorder (type 1) as a diagnosed condition
Baseline definition: indicator of 1+ principal discharge inpatient dx, 1+ primary ED dx, or 2+ outpatient dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first principal discharge inpatient dx, first primary ED dx, or second outpatient dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Bipolar-Dx
blind.dx
Short description: Blind in at least one eye as time-dependent covariate
Baseline definition: indicator of 1+ IP/ED/AV dx (need not be primary/principal) in the two years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first dx after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Blind-Dx
cad.dxpx.max
Short description: Coronary Artery Disease (CAD) as diagnosed comorbid condition (very high sensitivity)
Baseline definition: In the two years strictly prior to and including the patient’s index date, indicator of any of the following (whichever comes first): 1+ discharge inpatient dx, 1+ ED code, second outpatient or 1+ px.
Follow-up definition: date of the first discharge inpatient dx, first ED dx, second outpatient or first px (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
MI-Acute-Dx,
CABG-Stent-Px,
CAD-Dx
cad.dxpx.ppv
Short description: Coronary Artery Disease (CAD) as diagnosed comorbid condition (high positive predictive value)
Baseline definition: In the two years strictly prior to and including the patient’s index date, indicator of any of the following (whichever comes first): 1+ principal discharge inpatient dx, 1+ primary ED code, or 1+ px.
Follow-up definition: date of the first principal discharge inpatient dx, first primary ED code or first px (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
MI-Acute-Dx,
CABG-Stent-Px
cad.dxpx.sens
Short description: Coronary Artery Disease (CAD) as diagnosed comorbid condition (high sensitivity)
Baseline definition: In the two years strictly prior to and including the patient’s index date, indicator of any of the following (whichever comes first): 1+ principal discharge inpatient dx, 1+ primary ED code, or 1+ px.
Follow-up definition: date of the first principal discharge inpatient dx, first primary ED dx, or first px (whichever occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
MI-Acute-Dx,
CABG-Stent-Px,
CAD-Dx
cancer.mets.dx
Short description: Metastatic or very serious cancer as a diagnosed condition (Elixhauser definition)
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 2+ outpatient dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx, first ED dx, or second outpatient dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
CA-METS-Dx
cancer.nomets.dx
Short description: Non-metastatic cancer as a diagnosed condition (Elixhauser definition)
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 2+ outpatient dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx, first ED dx, or second outpatient dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
CA-NO-METS-Dx
cevd.dxpx.ppv
Short description: Cerebrovascular Disease (CeVD) as diagnosed comorbid condition (high positive predictive value)
Baseline definition: indicator of 1+ px, 1+ principal discharge inpatient dx, 1+ primary ED dx, in the two years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first principal discharge inpatient dx, first primary ED dx or first px (whichever of these dates occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
CeVD-Px,
CVA-EMB-Dx,
CVA-HEM-Dx
cevd.dxpx.sens
Short description: Cerebrovascular Disease (CeVD) as diagnosed comorbid condition (high sensitivity)
Baseline definition: In the two years strictly prior to and including the patient’s index date, indicator of any of the following (whichever comes first): (a) ANY inpatient dx or (b) ANY ED dx , (c) second outpatient dx, or (d) 1+ px.
Follow-up definition: after the patient’s index date, earliest date of any of the following (whichever comes first): (a) ANY inpatient dx, (b) ANY ED dx, (c) second outpatient dx, or (d) 1+ px.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
CeVD-Dx,
CeVD-Px,
CVA-EMB-Dx,
CVA-HEM-Dx
chf.dx.ppv
Short description: Congestive Heart Failure (CHF) as diagnosed comorbid condition (high positive predictive value)
Baseline definition: In the two years strictly prior to and including the patient’s index date, indicator of any of the following (whichever comes first): (a) ANY principal inpatient dx or (b) ANY primary ED dx.
Follow-up definition: after the patient’s index date, earliest date of any of the following (whichever comes first): (a) ANY principal inpatient dx or (b) ANY primary ED dx.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
CHF-Dx
chf.dx.sens
Short description: Congestive Heart Failure (CHF) as diagnosed condition (high sensitivity)
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 2+ outpatient dx in the two years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx, first ED dx, or second outpatient dx (whichever of the first inpatient dx, first ED dx, or second outpatient dx occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
CHF-Dx
ckd.dx
Short description: Chronic Kidney Disease (CKD) as a diagnosed condition
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 1+ outpatient dx in the 2 years strictly prior to or on the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx, first ED dx, or first outpatient dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
CKD-Dx
copd.dx
Short description: COPD as a diagnosed condition
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 2+ outpatient dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx, first ED dx, or second outpatient dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
COPD-Dx
covid_prd
Short description: COVID-19 pandemic indicator (starting 01/01/2020, date the first US cases were found)
Baseline definition: indicator of the index fill occuring before or after the start of the COVID-19 pandemic (01/01/2020)
Follow-up definition: indicator of follow-up time that coincides with the COVID-19 pandemic (01/01/2020 and onwards)
cysticfibrosis.dx
Short description: Cystic Fibrosis as a diagnosed condition
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 2+ outpatient dx in the 2 years prior to and including the index date.
Follow-up definition: date of the earliest discharge inpatient dx (need not be principal diagnosis), first ED dx (need not be primary ED diagnosis), or second outpatient dx after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
CysticFibrosis-Dx Notes:
-
This variable is intended as an exclusion if it occurs prior to and including the index date.
dementia.dx
Short description: Dementia as a diagnosed condition after the index date
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 1+ outpatient dx in the 2 years prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx, first ED dx, or first outpatient dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Dementia-Dx Notes: For analysis of drug impact on incident cases, exclude those with a dementia diagnosis on or prior to the index date.
depr.dx
Short description: New onset depression based on diagnosis data
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 1+ outpatient dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx, first ED dx, or first outpatient dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Depression-Dx Notes:
-
For analysis of drug impact on incident cases, exclude those with a depression diagnosis on or prior to the index date.
dka.dx
Short description: Diabetic ketoacidosis (DKA) or non-ketotic hyperosmolar state as an event
Baseline definition: indicator of a principal discharge inpatient dx, or a primary ED dx in the 2 years strictly prior to and including the patient’s index date (if more than one event, select the one closest to but prior to the index date).
Follow-up definition: date of a principal discharge inpatient dx, a primary ED dx (whichever of the inpatient dx or ED dx occurs earliest) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
DKA-Dx
esrd.dx
Short description: ESRD (End Stage Renal Disease) based on diagnosis codes
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 2+ outpatient dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the earliest discharge inpatient dx (need not be principal diagnosis), first ED dx (need not be primary ED diagnosis), or second outpatient dx after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
ESRD-Dx
esrd.px
Short description: ESRD Event (including Dialysis or Renal Transplant) as a time-dependent covariate based on Px codes
Baseline definition: From 1/1/2009 to the index date (including the index date) indicator of whether or not the patient met at least one of these two criteria: earliest date of a px code for renal transplantation (recipient); and/or earliest date of first of 10+ px codes for renal dialysis (hemodialysis or peritoneal dialysis).
Follow-up definition: Earliest date after index date on which the patient met one of these two criteria: earliest date of a px code for renal transplantation (recipient); and/or earliest date of first of 10+ px codes for renal dialysis (hemodialysis or peritoneal dialysis).
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
RenalTransplant-Px,
Dialysis-Px
etoh.dx
Short description: Alcohol use disorder as a diagnosed condition
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 1+ outpatient dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx, first ED dx, or first outpatient dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
EtOH-Dx
fasciitis.dx
Short description: Necrotizing fasciitis (also called Fournier’s gangrene) as a diagnosed condition
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 1+ outpatient dx between 1/1/2009 and the date strictly prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx, first ED dx, or first outpatient dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Fasciitis-Dx
frailty.dx
Short description: Frailty as a diagnosed condition
Baseline definition: indicator of 1+ discharge inpatient dx or 2+ outpatient dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx (need not be principal diagnosis) or second outpatient dx (whichever occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Frailty-Dx
htn.dx
Short description: Hypertension as a diagnosed condition
Baseline definition: indicator of 1+ discharge inpatient dx or 2+ outpatient dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx or second outpatient dx (whichever of the first inpatient dx or second outpatient dx occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
HTN-Dx
hypo.dx
Short description: diagnosed serious hypoglycemic event based on ED or hospital diagnosis
Baseline definition: indicator of 1+ principal discharge inpatient dx or 1+ primary ED dx in the two years strictly prior to and including the patient’s index date.
Follow-up definition: date of the earliest principal discharge inpatient dx, or earliest primary ED dx (whichever occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Hypo-Dx
hypothyroidism.dx
Short description: Hypothyroidism as a diagnosed condition
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 2+ outpatient dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx, first ED dx, or second outpatient dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Hypothyroid-Dx
leukemia.lymphoma.dx
Short description: Leukemia or Lymphoma as a diagnosed condition (Elixhauser definition)
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 2+ outpatient dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx, first ED dx, or second outpatient dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Leukemia-Lymphoma-Dx
lipid.dx
Short description: Dyslipidemia as a diagnosed condition
Baseline definition: indicator of any inpatient dx, any ED dx, or 2+ outpatient dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx, first ED dx, or second outpatient dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Lipids-Dx
liver.dx
Short description: Serious liver disease as a diagnosed condition
Baseline definition: indicator of 1+ principal discharge inpatient dx or 1+ primary ED dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first principal discharge inpatient dx or first primary ED dx, (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Liver-Dx Notes: This measure is based on Elixhauser classifications.
mci.dx
Short description: Mild Cognitive Impairment (MCI) as a diagnosed condition
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 1+ outpatient dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx, first ED dx, or first outpatient dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
MCI-Dx
men2.dx
Short description: Multiple Endocrine Neoplasia Type 2 based on diagnosis
Baseline definition: between 1/1/2009 to the index date (include the index date), one or more inpatient codes, or one or more ED codes, or 2 or more outpatient codes (take date of last outpatient code) from the indicated code list.
Follow-up definition: earliest date strictly after the index date (exclude the index date) of any of (a) one or more inpatient codes, (b) one or more ED codes, or (b) 2 or more outpatient codes (take date of earliest of 2 or more outpatient codes) from the indicated code list.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
MEN2-Dx
nephropathy.dx
Short description: Nephropathy as diagnosed condition
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 2+ outpatient dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx (need not be principal diagnosis), first ED dx, (need not be primary dx) or second outpatient dx (whichever occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Nephropathy-Dx
neuro.dx
Short description: Neurologic Condition as a diagnosed condition
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 2+ outpatient dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx, first ED dx, or second outpatient dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Neuro-Dx
pancreatitis.dx
Short description: Acute or Chronic Pancreatitis based on diagnosis
Baseline definition: between 1/1/2009 to the index date (include the index date), one or more inpatient codes, or one or more ED codes, or 2 or more outpatient codes (take date of most recent outpatient code) from the indicated code list.
Follow-up definition: earliest date strictly after the index date (exclude the index date) of any of (a) one or more inpatient codes, (b) one or more ED codes, or (c) 2 or more outpatient codes (take date of earliest of 2 or more outpatient codes) from the indicated code list.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Pancreatitis-Dx
pud.dx
Short description: Serious peptic ulcer disease as a diagnosed condition
Baseline definition: indicator of 1+ principal discharge inpatient dx or 1+ primary ED dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first principal discharge inpatient dx or first primary ED dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
PUD-Dx
pvd.dxpx.ppv
Short description: Peripheral Vascular Disease (PVD) as diagnosed comorbid condition (high positive predictive value)
Baseline definition: indicator of 1+ px, or 1+ principal discharge inpatient dx, in the 2 years strictly prior to and including the patient’s index date
Follow-up definition: date of the first principal discharge inpatient dx, or first px (whichever of the first inpatient dx or first px occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
PVD-Dx,
PVD-Px Notes: Amputations not included.
pvd.dxpx.sens
Short description: Peripheral Vascular Disease (PVD) as diagnosed comorbid condition (high sensitivity)
Baseline definition: indicator of 1+ px, 1+ discharge inpatient dx, 1+ primary ED dx, or 2+ outpatient dx in the 2 years strictly prior to and including the patient’s index date
Follow-up definition: date of the first discharge inpatient dx, first primary ED dx, second outpatient dx, or first px (whichever of these dates occurs first) after the patient’s index date
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
PVD-Dx,
PVD-Px Notes: Amputations not included.
pyelo.dx
Short description: Pyelonephritis as a diagnosed condition
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 1+ outpatient dx from 01/01/2009 up to and including the patient’s index date
Follow-up definition: date of the first discharge inpatient dx, first ED dx, or first outpatient dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Pyelo-Dx
retinopathy.dxpx
Short description: Proliferative Retinopathy as time-dependent covariate
Baseline definition: indicator of 1+ discharge inpatient dx (does not need to be principal dx code), or 2+ outpatient dx or 1+ px in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx, second outpatient dx, or first px (whichever occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Retinopathy-Dx,
Retinopathy-Px
schiz.dx
Short description: Schizophrenia and schizoaffective disorder as diagnosed conditions
Baseline definition: indicator of 1+ principal discharge inpatient dx, 1+ primary ED dx, or 2+ outpatient dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first principal discharge inpatient dx, first primary ED dx, or second outpatient dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Schiz-Dx
sud.dx
Short description: A set of substance use disorders (including only opioid, cocaine, amphetamine, and hallucinogen use disorders) based on diagnosis data
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 1+ outpatient dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx, first ED dx, or first outpatient dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
SUD-Dx Notes:
-
These include opioid, amphetamine, cocaine, and hallucinogen use disorders that are not coded as resolved.
-
These do not include alcohol use disorder or tobacco use disorder, which are coded as separate variables. They also do not include cannabis or sedative/hypnotic use disorders.
-
If in remission, not coded.
valvular.dx
Short description: Valvular Heart Disease (Mitral or Aortic) as a diagnosed condition
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 2+ outpatient dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx, first ED dx, or second outpatient dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Aortic-or-Mitral-Valve-Dx Notes: This includes rheumatic valvular heart disease, and congenital valvular heart disease.
vasculitis.dx
Short description: Connective Tissue Disease as a diagnosed condition
Baseline definition: indicator of 1+ discharge inpatient dx, 1+ ED dx, or 2+ outpatient dx in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: date of the first discharge inpatient dx, first ED dx, or second outpatient dx (whichever of these occurs first) after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Vasculitis-Dx
Interval
Description: categorical or continuous time dependent variable without missing values (ex: prescriptions)
For each variable, we describe first the distribution of its baseline value and second we provide three measures of the frequency at which the values of the variable change during follow-up. The first measure (given in the title of subsections) is a single ratio of the number of changes in value during follow-up (after month 1) by the total number of follow-up month (multiplied by 12 so it can be interpreted as an average number of value changes per year). The second measure is the distribution of the ratio just described when it is computed separately for each patient-index dispensings. The third measure is the distribution of the previous ratios for patient-index dispensings who are followed up for at least one year after the first month.
Medication Exposure to Specific Drug X (with 90-day extension) as a Time-Dependent Covariate (High Sensitivity Method)
Short description: This variable defines exposure on a specific Drug X on a specific Day “d.” This variable applies ONLY to any one of the specific drugs listed below on “Drug List X.”
Baseline definition: 1 if patient exposed to the drug on day before index date and 0 otherwise
Follow-up definition: (Persistence based on Fills) For each follow-up day (day “d”) starting on the index date, 1 if the patient is exposed to the drug on the given follow-up day and 0 otherwise
-
Exposure status definition on Date “d”:
-
Step 1a): Multiply the “days supplied” on the most recent drug dispensing of Specific Drug X prior to day d by a factor of 2. Add this to the drug dispensing date, and designate this new date as date “A.”
-
Step 1b) If date “d” occurs before Date “A,” STOP and designate the patient as exposed to this medication on date “d.” Otherwise, continue on to Step 2 below:
-
Step 2a): If and only if there is a subsequent drug dispensing of the same medication within 90 days after Date “A” add 90 days to Date “A” and designate this result as Date “B.”
-
Step 2b) If date “d” occurs before Date “B” STOP and designate the patient as exposed to Drug X on date “d.” Otherwise, designate the patient as NOT EXPOSED to Specific Drug X on date “d.”
Data Source: See tab for each drug on the list of “Specific Drug X” on the spreadsheet of relevant dispensing NDC codes for a specific Drug X.
Notes:
-
When the unit of time in the analysis is a time interval “t” (e.g. 30 days): exposed status for interval “t” is set to 1 if the patient was deemed exposed on any day within time interval “t”.
-
If fill has a days supply greater than 400, then truncate it to be 400.
aa
Short description: Amylin Analogs
Data Source: Relevant dispensing NDC codes are listed in this code list file: not available
Procedure: Refer to “Medication Exposure” entry for procedure
aceinhibitors
Short description: Angiotensin-Converting Enzyme (ACE) Inhibitors
Data Source: Relevant dispensing NDC codes are listed in this code list file:
ACEInhibitors Procedure: Refer to “Medication Exposure” entry for procedure
agi
Short description: Alpha-Glucosidase Inhibitors
Data Source: Relevant dispensing NDC codes are listed in this code list file: not available
Procedure: Refer to “Medication Exposure” entry for procedure
anticoagulants
Short description: Anticoagulants
Data Source: Relevant dispensing NDC codes are listed in this code list file:
Anticoagulants Procedure: Refer to “Medication Exposure” entry for procedure
anticonvulsants
Short description: Anticonvulsants
Data Source: Relevant dispensing NDC codes are listed in this code list file:
Anticonvulsants Procedure: Refer to “Medication Exposure” entry for procedure
antidepressantcomb
Short description: Antidepressant Combo
Data Source: Relevant dispensing NDC codes are listed in this code list file:
AntidepressantComb Procedure: Refer to “Medication Exposure” entry for procedure
antidepressantmaoi
Short description: Antidepressant MAOI
Data Source: Relevant dispensing NDC codes are listed in this code list file:
AntidepressantMAOI Procedure: Refer to “Medication Exposure” entry for procedure
antidepressantndri
Short description: Antidepressant NDRI
Data Source: Relevant dispensing NDC codes are listed in this code list file:
AntidepressantNDRI Procedure: Refer to “Medication Exposure” entry for procedure
antidepressantother
Short description: Antidepressant Other
Data Source: Relevant dispensing NDC codes are listed in this code list file:
AntidepressantOther Procedure: Refer to “Medication Exposure” entry for procedure
antidepressantsari
Short description: Antidepressant SARI
Data Source: Relevant dispensing NDC codes are listed in this code list file:
AntidepressantSARI Procedure: Refer to “Medication Exposure” entry for procedure
antidepressantsnri
Short description: Antidepressant SNRI
Data Source: Relevant dispensing NDC codes are listed in this code list file:
AntidepressantSNRI Procedure: Refer to “Medication Exposure” entry for procedure
antidepressantspo
Short description: Antidepressant SPO
Data Source: Relevant dispensing NDC codes are listed in this code list file:
AntidepressantSPO Procedure: Refer to “Medication Exposure” entry for procedure
antidepressantssri
Short description: Antidepressant SSRI
Data Source: Relevant dispensing NDC codes are listed in this code list file:
AntidepressantSSRI Procedure: Refer to “Medication Exposure” entry for procedure
antidepressanttca
Short description: Antidepressant TCA
Data Source: Relevant dispensing NDC codes are listed in this code list file:
AntidepressantTCA Procedure: Refer to “Medication Exposure” entry for procedure
antidepressantteca
Short description: Antidepressant TeCA
Data Source: Relevant dispensing NDC codes are listed in this code list file:
AntidepressantTeCA Procedure: Refer to “Medication Exposure” entry for procedure
antiplatelets
Short description: Antiplatelet Medications
Data Source: Relevant dispensing NDC codes are listed in this code list file:
AntiPlatelets Procedure: Refer to “Medication Exposure” entry for procedure
antipsychotic1stgen
Short description: 1st Generation Antipsychotics
Data Source: Relevant dispensing NDC codes are listed in this code list file:
Antipsychotic1stGen Procedure: Refer to “Medication Exposure” entry for procedure
antipsychotic2ndgen
Short description: 2nd Generation Antipsychotics
Data Source: Relevant dispensing NDC codes are listed in this code list file:
Antipsychotic2ndGen Procedure: Refer to “Medication Exposure” entry for procedure
anxiety
Short description: Anxiety Medications
Data Source: Relevant dispensing NDC codes are listed in this code list file:
Anxiety Procedure: Refer to “Medication Exposure” entry for procedure
arb
Short description: Angiotensin Receptor Blockers (ARB)
Data Source: Relevant dispensing NDC codes are listed in this code list file:
ARB Procedure: Refer to “Medication Exposure” entry for procedure
benzodiazepines
Short description: Benzodiazepines
Data Source: Relevant dispensing NDC codes are listed in this code list file:
Benzodiazepines Procedure: Refer to “Medication Exposure” entry for procedure
betablockers
Short description: Beta Blockers
Data Source: Relevant dispensing NDC codes are listed in this code list file:
BetaBlockers Procedure: Refer to “Medication Exposure” entry for procedure
clonidine
Short description: Clonidine
Data Source: Relevant dispensing NDC codes are listed in this code list file:
Clonidine Procedure: Refer to “Medication Exposure” entry for procedure
dihydropyridineccb
Short description: Dihydropyridine Calcium Channel Blockers
Data Source: Relevant dispensing NDC codes are listed in this code list file:
DihydropyridineCCB Procedure: Refer to “Medication Exposure” entry for procedure
dpp4
Short description: Dipeptidyl Peptidase-4 Inhibitors
Data Source: Relevant dispensing NDC codes are listed in this code list file: not available
Procedure: Refer to “Medication Exposure” entry for procedure
hypnoticother
Short description: Other Hypnotic
Data Source: Relevant dispensing NDC codes are listed in this code list file:
HypnoticOther Procedure: Refer to “Medication Exposure” entry for procedure
injectableantipsychotic
Short description: Injectable Antipsychotics
Data Source: Relevant dispensing NDC codes are listed in this code list file:
InjectableAntipsychotic Procedure: Refer to “Medication Exposure” entry for procedure
ins
Short description: Insulins
Data Source: Relevant dispensing NDC codes are listed in this code list file: not available
Procedure: Refer to “Medication Exposure” entry for procedure
ins_analog
Short description: Analog Type Insulins
Data Source: Relevant dispensing NDC codes are listed in this code list file: not available
Procedure: Refer to “Medication Exposure” entry for procedure
ins_combo
Short description: Combo Duration Insulins
Data Source: Relevant dispensing NDC codes are listed in this code list file: not available
Procedure: Refer to “Medication Exposure” entry for procedure
ins_commercial
Short description: Whether the person had any commercial insurance coverage during the period
Baseline definition: Assign a 0/1 flag to indicate that this insurance type applies to a patient on the index date or within the 30-day period prior to the index date.
Follow-up definition: For each defined time interval or date, assign a 0/1 flag to indicate that this insurance type applies to a patient on the indicated date, or for any date within the indicated range of dates.
Data Source: VDW Enrollment
ins_highdeductible
Short description: Whether the person had any insurance coverage in a high deductible plan during the period as defined by the U.S. IRS (Pub 969) qualifying for a Health Savings Account
Baseline definition: Assign a 0/1 flag to indicate that this insurance type applies to a patient on the index date or within the 30-day period prior to the index date.
Follow-up definition: For each defined time interval or date, assign a 0/1 flag to indicate that this insurance type applies to a patient on the indicated date, or for any date within the indicated range of dates.
Data Source: VDW Enrollment
ins_human
Short description: Human Type Insulins
Data Source: Relevant dispensing NDC codes are listed in this code list file: not available
Procedure: Refer to “Medication Exposure” entry for procedure
ins_la
Short description: Long Acting Duration Insulins
Data Source: Relevant dispensing NDC codes are listed in this code list file: not available
Procedure: Refer to “Medication Exposure” entry for procedure
ins_medicaid
Short description: Whether the person had any Medicaid insurance coverage during the period
Baseline definition: Assign a 0/1 flag to indicate that this insurance type applies to a patient on the index date or within the 30-day period prior to the index date.
Follow-up definition: For each defined time interval or date, assign a 0/1 flag to indicate that this insurance type applies to a patient on the indicated date, or for any date within the indicated range of dates.
Data Source: VDW Enrollment
ins_medicare
Short description: Whether the person had any Medicare insurance coverage, including Medicare working aged, during the period
Baseline definition: Assign a 0/1 flag to indicate that this insurance type applies to a patient on the index date or within the 30-day period prior to the index date.
Follow-up definition: For each defined time interval or date, assign a 0/1 flag to indicate that this insurance type applies to a patient on the indicated date, or for any date within the indicated range of dates.
Data Source: VDW Enrollment
ins_medicare_a
Short description: Whether the person had Medicare Part A insurance coverage during the period
Baseline definition: Assign a 0/1 flag to indicate that this insurance type applies to a patient on the index date or within the 30-day period prior to the index date.
Follow-up definition: For each defined time interval or date, assign a 0/1 flag to indicate that this insurance type applies to a patient on the indicated date, or for any date within the indicated range of dates.
Data Source: VDW Enrollment
ins_medicare_b
Short description: Whether the person had Medicare Part B insurance coverage during the period
Baseline definition: Assign a 0/1 flag to indicate that this insurance type applies to a patient on the index date or within the 30-day period prior to the index date.
Follow-up definition: For each defined time interval or date, assign a 0/1 flag to indicate that this insurance type applies to a patient on the indicated date, or for any date within the indicated range of dates.
Data Source: VDW Enrollment
ins_medicare_c
Short description: Whether the person had Medicare Part C insurance coverage during the period
Baseline definition: Assign a 0/1 flag to indicate that this insurance type applies to a patient on the index date or within the 30-day period prior to the index date.
Follow-up definition: For each defined time interval or date, assign a 0/1 flag to indicate that this insurance type applies to a patient on the indicated date, or for any date within the indicated range of dates.
Data Source: VDW Enrollment
ins_medicare_d
Short description: Whether the person had Medicare Part D insurance coverage during the period
Baseline definition: Assign a 0/1 flag to indicate that this insurance type applies to a patient on the index date or within the 30-day period prior to the index date.
Follow-up definition: For each defined time interval or date, assign a 0/1 flag to indicate that this insurance type applies to a patient on the indicated date, or for any date within the indicated range of dates.
Data Source: VDW Enrollment
ins_other_coverage
Short description: Whether the person had insurance coverage during the period that is not otherwise included in the INS variables during the period
Baseline definition: Assign a 0/1 flag to indicate that this insurance type applies to a patient on the index date or within the 30-day period prior to the index date.
Follow-up definition: For each defined time interval or date, assign a 0/1 flag to indicate that this insurance type applies to a patient on the indicated date, or for any date within the indicated range of dates.
Data Source: VDW Enrollment
ins_privatepay
Short description: Whether the person had any insurance coverage in a private pay plan during the period
Baseline definition: Assign a 0/1 flag to indicate that this insurance type applies to a patient on the index date or within the 30-day period prior to the index date.
Follow-up definition: For each defined time interval or date, assign a 0/1 flag to indicate that this insurance type applies to a patient on the indicated date, or for any date within the indicated range of dates.
Data Source: VDW Enrollment
ins_sa
Short description: Short Acting Duration Insulins
Data Source: Relevant dispensing NDC codes are listed in this code list file: not available
Procedure: Refer to “Medication Exposure” entry for procedure
ins_selffunded
Short description: Whether the person had any insurance coverage through an employer group that insures itself during the period
Baseline definition: Assign a 0/1 flag to indicate that this insurance type applies to a patient on the index date or within the 30-day period prior to the index date.
Follow-up definition: For each defined time interval or date, assign a 0/1 flag to indicate that this insurance type applies to a patient on the indicated date, or for any date within the indicated range of dates.
Data Source: VDW Enrollment
ins_statesubsidized
Short description: Whether the person had any state subsidized insurance coverage during the period
Baseline definition: Assign a 0/1 flag to indicate that this insurance type applies to a patient on the index date or within the 30-day period prior to the index date.
Follow-up definition: For each defined time interval or date, assign a 0/1 flag to indicate that this insurance type applies to a patient on the indicated date, or for any date within the indicated range of dates.
Data Source: VDW Enrollment
ksparingdiuretics
Short description: K Sparing Diuretics
Data Source: Relevant dispensing NDC codes are listed in this code list file:
KSparingDiuretics Procedure: Refer to “Medication Exposure” entry for procedure
lithium
Short description: Lithium
Data Source: Relevant dispensing NDC codes are listed in this code list file:
Lithium Procedure: Refer to “Medication Exposure” entry for procedure
loopdiuretics
Short description: Loop Diuretics
Data Source: Relevant dispensing NDC codes are listed in this code list file:
LoopDiuretics Procedure: Refer to “Medication Exposure” entry for procedure
meg
Short description: Meglitinides
Data Source: Relevant dispensing NDC codes are listed in this code list file: not available
Procedure: Refer to “Medication Exposure” entry for procedure
met
Short description: Biguanides
Data Source: Relevant dispensing NDC codes are listed in this code list file: not available
Procedure: Refer to “Medication Exposure” entry for procedure
nondihydropyridineccb
Short description: Non-Dihydropyridines Calcium Channel Blockers
Data Source: Relevant dispensing NDC codes are listed in this code list file:
NonDihydropyridineCCB Procedure: Refer to “Medication Exposure” entry for procedure
otherlipidmeds
Short description: Other Lipid Medications
Data Source: Relevant dispensing NDC codes are listed in this code list file:
OtherLipidMeds Procedure: Refer to “Medication Exposure” entry for procedure
pcsk9mab
Short description: PCSK9 Monoclonal Antibodies
Data Source: Relevant dispensing NDC codes are listed in this code list file:
PCSK9mAB Procedure: Refer to “Medication Exposure” entry for procedure
pregnancy
Short description: Pregnancy as ascertained in each sites CESR or home grown pregnancy outcome table
Baseline definition: Baseline pregnancy value is set to 0 for all index fills because pregnancy on the index date is an exculsion criteria for all subcohorts.
Follow-up definition: For each defined time interval or date, assign a 0/1 flag to indicate that the patient had a pregnancy on the indicated date, or for any date within the indicated range of dates.
Data Source: CESR Pregnancy or homegrown
Notes:
-
Sites with CESR tables: KPNC, KPSC, KPHI
-
Sites with homegrown tables: HPI, HFHS, GHS
statins
Short description: Statins
Data Source: Relevant dispensing NDC codes are listed in this code list file:
Statins Procedure: Refer to “Medication Exposure” entry for procedure
stimulants
Short description: Stimulants
Data Source: Relevant dispensing NDC codes are listed in this code list file:
Stimulants Procedure: Refer to “Medication Exposure” entry for procedure
sunew
Short description: Sulfonylureas
Data Source: Relevant dispensing NDC codes are listed in this code list file: not available
Procedure: Refer to “Medication Exposure” entry for procedure
suold
Short description: Sulfonylureas
Data Source: Relevant dispensing NDC codes are listed in this code list file: not available
Procedure: Refer to “Medication Exposure” entry for procedure
thiazidediuretics
Short description: Thiazide Diuretics
Data Source: Relevant dispensing NDC codes are listed in this code list file:
ThiazideDiuretics Procedure: Refer to “Medication Exposure” entry for procedure
tir
Short description: Tirzepatide
Data Source: Relevant dispensing NDC codes are listed in this code list file: not available
Procedure: Refer to “Medication Exposure” entry for procedure
tzd
Short description: Thiazolidinediones
Data Source: Relevant dispensing NDC codes are listed in this code list file: not available
Procedure: Refer to “Medication Exposure” entry for procedure
dka.dx.count
Short description: Count of diabetic ketoacidosis (DKA) or non-ketotic hyperosmolar state events
Baseline definition: count of number of hospital admissions with a principal discharge diagnosis or ED visits with a primary diagnosis of this condition strictly prior to and including the patient’s index date.
Follow-up definition: count of number of hospitalizations with a principal hospital discharge diagnosis or ED visits with a primary diagnosis for this condition after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
DKA-Dx Notes:
-
If an ED visit leads to an admission, this counts as one event. If both an ED and inpatient diagnosis of this condition occur on the same day, or if they occur on consecutive days, count as one event,.
hypo.dx.count
Short description: Count of hypoglycemic events
Baseline definition: Count of number of hospital admissions (principal or not) or ED visits (primary or not) with an indicator for this condition in the 2 years strictly prior to and including the patient’s index date.
Follow-up definition: Count of number of hospital admissions (principal or not) or ED visits (primary or not) with an indicator for this condition after the patient’s index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
Hypo-Dx Notes:
-
If an ED visit leads to an admission, this counts as one event. If both an ED and inpatient diagnosis of this condition occur on the same day, or if they occur on consecutive days, count as one event.
Time-independent
Description: time independent variables that can be missing (ex: age at baseline)
a1c_age
Short description: Age of the Baseline A1c Measure
Description:
-
Age of the baseline A1c measure relative to the index date, captures how old the A1c collected in the last 24 months is.
-
Categorized into the following categories: index date to 182 days prior to the index date, 183 to 365 days prior to the index date, 366 to 547 days prior to the index date, 548 to 730 days prior to the index date, and 731 days prior to the index date.
-
Acceptable values: 1 to 25%
-
All encounter types
-
If two measures on one day, take last measure
-
Take all measures (inpatient, outpatient, ER)
-
If two measures on same day and same time stamp, use highest value
-
Units: %, keep missing if in range
Data Source: VDW lab table
acc_aha_201310yrcvdrisk
Short description: Baseline CVD risk score
Description:
-
Baseline CVD risk score using the ACC/AHA 10-Year Pooled CVD Risk Equation, based on most recent data for each included variable in the 2 years prior to and including the index date (except current smoker status, which looks back to 1/1/2009, the earliest data available).
-
Inputs include:
-
Age (must be between 40-79)
-
Sex (male or not)
-
Race (non-Hispanic African American or not)
-
Systolic blood pressure (SBP, mmHG, most recent outpatient BP)
-
TCL (total cholestrol, mg/DL, most recent outpatient lab)
-
HDL (HFL cholesterol, mg/DL, most recent outpatient lab)
-
Current smoker (yes/no)
-
Diabetes (yes/no, exclusion criteria requires all patients to have T2DM, so is set to yes for all patients)
-
Hypertension medication use (yes/no, at least one outpatient diagnosis of hypertension based on ICD 9 or ICD 10 codes and any anti-hypertensive medication use within 2 year of hypertension diagnosis, medication use can occur before or after diagnosis).
-
If necessary, impute TCL and HDL from partial lipid data, using HealthPartners Wizard CDS algorithms (see procedure section).
Procedure: Other or Unknown Sex:
-
These patients are treated as female when calculating the equation TCL and HDL Imputation (HealthPartners Wizard CDS):
-
If BOTH TCL and LDL are missing then neither TCL or LDL can be imputed and risk score should be missing
-
If HDL is missing then impute it with 40 if patient is male and 50 if patient is female or other/unknown sex
-
If TRIG is missing then impute it with 150
-
If TCL is missing then LDL is not (see first bullet) so impute TCL with LDL+HDL+TRIG/5 Age: Equation target population is adults aged 40-79 years
-
If patient age is less than 40, replace age with 40 when computing equation
-
If patient age is greater than 79, replace age with 79 when computing equation SBP (systolic blood pressure):
-
If SBP is missing then risk score should be missing Ignored Target Population Criteria:
-
Equation target popution had no previous statin or other lipid-lowering therapy use, we ignore this requirement and thus allow patients to have previous statin/lipid-lowering therapy use
-
Equation target population required patients to have an outpatient LDL-C measurement between 70-189 mg/dL, we allow LDL measurements outside this range
Reference: ACC/AHA 10-year CVD Pooled Risk Equation: Goff D, et al. Circulation 2013. Table A (equation parameters):
https://www.ahajournals.org/doi/full/10.1161/01.cir.0000437741.48606.98#T1a Table B (step-by-step equation explanation):
https://www.ahajournals.org/doi/full/10.1161/01.cir.0000437741.48606.98#T1b
age
Short description: Age on index date in years, based on birthday in VDW Demographics table
Data Source: VDW Demographics table
chf.dx.status
Short description: Baseline Congestive Heart Failure (CHF) status
Description: Three levels:
-
Those with 0 ER/IP/AV dx in the baseline period (denoted by a 0)
-
Those with any ER/IP/2+AV dx in the baseline period (denoted by a 1)
-
Those with only 1 outpatient dx with no ER/IP dx in the baseline period (denoted by 999)
Baseline definition: Two years lookback and strictly prior to and including the index date.
Data Source: Relevant codes are listed with a “Y” in the COVARIATE column of the following code list file(s):
CHF-Dx Procedure: Before analyzing remove 999 group, only use 1/0 for subgroup analysis.
cv_risk_subgrp
Short description: Subgroup defined based on CVD risk score at baseline
Description:
-
ACC_AHA_201310yrCVDrisk = original continuous score in the dataset
-
Discretize the continuous variable ACC_AHA_201310yrCVDrisk, corresponding with the data dictionary entry titled “Baseline CVD risk score“:
-
Three categories based on two cutoffs 10% & 20%: <10 (Low); [10,20) (Moderate); >=20 (High); those missing a ASCVD risk score are classified as Unknown
-
Patients with ASCVD.DxPx.PPV=1 are classified as OTHER and ignored for subgroup analysis
diab_duration
Description: We will consider diabetes onset as the earlier of one inpatient diagnosis (see tab “T2D-Dx” in code list, COVARIATE=‘Y’ only) or any combination of two of the following events occurring in lookback period (back to January 1st, 2009) prior to and including index, using the date of the first event in the pair as the identification date:
-
A1C >= 6.5% (48 mmol/mol)
-
Fasting plasma glucose >= 126 mg/dl (7.0 mmol/L)
-
Random plasma glucose >= 200 mg/dl (11.1 mmol/L)
-
An outpatient diagnosis code (same codes as inpatient)
-
Any anti-hyperglycemic medication dispensings For example, an individual with an A1C of 7.5% (57 mmol/mol) followed by an outpatient diagnosis of diabetes would be identified with diabetes on the (earlier) date of the A1C, with a laboratory result as the primary source. When the two events used for identification come from the same source (e.g. two outpatient diagnoses), we will require them to occur on separate dates, but no more than 24-months apart. Thus, the pair of events could span more than one calendar year. If this were to occur, the incident case will be assigned to the year in which the earlier event was identified. Note the following exception: two dispensings of metformin, thiazolidinediones, or liraglutide – with no other indication of diabetes – will be not counted because these agents could be used for diabetes prevention, weight loss or to treat polycystic ovarian syndrome. Events that are identified during a pregnancy (start and end dates defined by the study pregnancy table) will be excluded from consideration.
-
This variable is treated both as a subgroup variable and a time-independent covariate.
ethnicity
Short description: Indicator of Hispanic ethnicity from VDW Demographics table, separate from race variable
Description: Possible values: Hispanic or Non-Hispanic
Data Source: VDW Demographics table
Notes: Also used as a subgroup variable.
female_head_of_hh
Short description: Proportion of households headed by females (no male present)
Data Source: VDW census demog acs
hh_public_assistance
Short description: Proportion of households on public assistance
Data Source: VDW census demog acs
household_income_less_30k
Short description: Percent of households with household income less than $30,000 per year
Data Source: VDW census demog acs
Procedure: Calculated by adding HOUSINCOME1-5 (each includes HH annual income in $5000 increments, except HOUSINCOME1 which is <$10,000)
houspoverty
Short description: Percent of households with below-poverty level income
Data Source: VDW census demog acs
index_yr
Short description: Year the index fill occured
low_educ
Short description: Proportion of persons with less than a 12th-grade education
Data Source: VDW census demog acs
Procedure: Calculated by adding EDUCATION1 (proportion with less than 9th grade) and EDUCATION2 (proportion with 9th-12th grade, and not a high school graduate)
mgr_male
Short description: Proportion of male management occupations
Data Source: VDW census demog acs
ndi
Short description: Neighborhood Deprivation Index
Procedure: Equation from Berkowitz et al.: NDI Score = (.397)(pct_hh_poverty) + (.357)(fem_hh_w_dep) + (.386)(hh_less_30k) + (0.382)(hh_w_publa) + (-0.285)(male_mngmt) + (.261)(crowded) + (.366)(pct_unemp) + (.369)(low_educ)
Reference: See Berkowitz et al. 2014 (HSR appendix), DOI: 10.1111/1475-6773.12229 for NDI calculation
only_met_no_ascvd
Short description: Subgroup defined based on baseline T2DM drug exposure
Description: T2DM drug classes: AA, AGI, DPP4, GLP1, INS, MEG, MET, SGLT2, SUnew, SUold, and TZD (note that depending on the subcohort being analyzed two of these will not be included as a covariate, i.e. for SU vs SGLT2 there will be no SUnew or SGLT2 covariate, etc.)
-
Initiation of new drugs in moderate CVD group after metformin monotherapy, i.e ASCVD.Dx.Px.Max=0 and Index.MET=1 at baseline and index.*=0 for all other T2DM drug classes
Data Source: VDW Rx table
only_met_therapy
Short description: Subgroup defined based on baseline T2DM drug exposure
Description: T2DM drug classes: AA, AGI, DPP4, GLP1, INS, MEG, MET, SGLT2, SUnew, SUold, and TZD (note that depending on the subcohort being analyzed two of these will not be included as a covariate, i.e. for SU vs SGLT2 there will be no SUnew or SGLT2 covariate, etc.)
-
Identify patients who were on only metformin therapy at baseline, i.e. index.MET=1 and index.*=0 for all other T2DM drug classes (insulin, SGLT2, GLP1, DPP4, AGI, etc)
Data Source: VDW Rx table
pct_crowding
Short description: Proportion of households with >= 1 person per room
Data Source: VDW census demog acs
racegrp
Short description: Racial categories based on Race1-5 columns from VDW Demographics table
Description: Possible values: Black or African American, Hawaiian or Pacific Islander, Asian, American Indian or Alaska Native, White, Other, Unknown, or Multi-race
Data Source: VDW Demographics table
Procedure: If multiple races specified in Race1-5 then classify as multiracial, otherwise if only one race is specified in Race1-5 (and rest are missing or the same race) then classify as that race. If all are missing then classify as unknown.
Reference: See the following JAMA article for guidelines,
https://jamanetwork.com/journals/jama/fullarticle/2783090 Notes: Also used as a subgroup variable.
renal_function_status
Short description: Subgroup defined based on renal function
Description:
-
Categorize renal function status/prognosis of CKD based on National Kidney Foundation heatmap
-
Compare albuminuria and 2021 eGFR categories to classify the patients as follows:
-
Low Risk
-
Moderate Risk
-
High Risk
-
Very High Risk
-
Unknown (if eGFR or ACR are missing)
Data Source: VDW lab table
Procedure: Albuminuria:
-
Plausible ACR Range: 0 to 600 mg albumin per gram of creatinine
-
Only take outpatient (no ER, no inpatient)
-
If two measures on one day, take lowest measure, regardless of time
-
Units: MG/G CREAT, MG/G{CREAT}, and UG/MG CREAT
-
Classify albuminuria as follows based on designated ACR:
-
A1: Classify as 0 if < 30 [normal]
-
A2: Classify as 1 if 30 to < 250 [moderate]
-
A3: Classify as 2 if >= 250 [high]
-
Cut off at 250 is due to KPNC using this cutoff and not reporting specific values > 250 eGFR-2021:
-
Plausible values: 0-200 ml/min/1.73m2
-
Only take outpatient (no ER, no inpatient)
-
Values on or before index date (most recent, up to 2 years prior to index date) are considered baseline
-
Sex value other than male or female is treated as female since eGFR is non-defined for non-male/female sex and female results in a lower eGFR value when other terms are held constant
-
If more than one eGFR on one day, take highest value
-
Classify as follows based on designated eGFR:
-
G1: >= 90 [normal or high]
-
G2: 60 to < 90 [mildly decreased]
-
G3a: 45 to < 60 [mildly to moderately decreased]
-
G3b: 30 to < 45 [moderately to severely decreased]
-
G4: 15 to < 30 [severely decreased]
-
G5: < 15 [kidney failure]
Reference:
sex
Short description: Sex at birth as listed in VDW Demographics table
Description: Possible values: Male, Female, Other, and Unknown
Data Source: VDW Demographics table
site
total_visit_c
Short description: Total number of visits to an cardiologist at baseline
Description:
-
Count of cardiologist visits 2 years prior to and including the index date
-
Outpatient and virtual care encounters only
-
Only count encounters with a provider that has a SPECIALTY column value of ‘CAR’, ‘CAV’, ‘VAS’, or ‘CLC’ regardless of the department encounter occured in
Data Source: VDW utilization and provider specialty table
total_visit_e
Short description: Total number of visits to an endocrinologist at baseline
Description:
-
Count of endocrinologist visits 2 years prior to and including the index date
-
Outpatient and virtual care encounters only
-
Only count encounters with a provider that has a SPECIALTY column value of ‘END’ regardless of the department encounter occured in
Data Source: VDW utilization and provider specialty table
total_visit_n
Short description: Total number of visits to a nephrologist at baseline
Description:
-
Count of nephrologist visits 2 years prior to and including the index date
-
Outpatient and virtual care encounters only
-
Only count encounters with a provider that has a SPECIALTY column value of ‘NEH’ regardless of the department encounter occured in
Data Source: VDW utilization and provider specialty table
unemployment
Short description: Proportion of civilian noninstitutionalized population between 18 and 64 who are unemployed
Data Source: VDW census demog acs
Sporadic
Description: categorical or continuous time dependent variable with possibly missing values (ex: lab measurements)
For each variable, we describe first the distribution of its baseline value and second we provide three measures of the frequency at which the values of the variable change during follow-up. The first measure (given in the title of subsections) is a single ratio of the number of changes in value during follow-up (after month 1) by the total number of follow-up month (multiplied by 12 so it can be interpreted as an average number of value changes per year). The second measure is the distribution of the ratio just described when it is computed separately for each patient-index dispensings. The third measure is the distribution of the previous ratios for patient-index dispensings who are followed up for at least one year after the first month.
a1c
Short description: A1c (Glycated Hemoglobin) reported as %
Description:
-
Acceptable values: 1 to 25%
-
All encounter types
-
If two measures on one day, take last measure
-
Take all measures (inpatient, outpatient, ER)
-
If two measures on same day and same time stamp, use highest value
-
Units: %, keep missing if in range
Baseline definition: The most recent measure (if one exists) in the time period 2 years before or on the index date.
Follow-up definition: Measures that occur after the index date.
Data Source: VDW lab table
acr
Short description: Urinary Albumin Creatinine Ratio
Description:
-
Plausible ACR Range: 0 to 600 mg albumin per gram of creatinine
-
Only take outpatient (no ER, no inpatient)
-
If two measures on one day, take lowest measure, regardless of time
-
Units: MG/G CREAT, MG/G{CREAT}, and UG/MG CREAT
Baseline definition: The most recent measure (if one exists) in the time period 2 years before or on the index date.
Follow-up definition: Measures that occur after the index date.
Data Source: VDW lab table
Notes:
-
Cut off at 250 is due to KPNC using this cutoff and not reporting specific values > 250.
alt
Short description: ALT (U/L) liver function test
Description:
-
Plausible values: 0-10,000
-
Only take outpatient (no ER, no inpatient)
-
If same date and time stamp, take lowest measure
-
If two measures on one day, take last measure
-
Units: U/L for all sites, keep missing as long as in range for all sites
Baseline definition: The most recent measure (if one exists) in the time period 2 years before or on the index date.
Follow-up definition: Measures that occur after the index date.
Data Source: VDW lab table
bmi
Short description: BMI
Description:
-
Calculated from height (HT, measured in inches) and weight (WT, measured in pounds) in VDW vital signs table
-
Acceptable value range for height: 40-90 inches
-
Acceptable value range for weight: 66-462 pounds
-
Select only outpatient values, no inpatient, no ER, no virtual care
-
If weight outside acceptable range, use closest prior weight measure if it is in the acceptable range
-
Use median height based on all outpatient height values from 1/1/2009 to the last available height measurement in the Vitals data.
-
For formula to calculate BMI, multiple weight in pounds by 0.45359237 to get weight in kilograms, and multiple height in inches by 0.0254 to get height in meters
-
BMI = (weight in pounds x 0.45359237)/((height in inches x 0.0254) x (height in inches x 0.0254))
-
Round BMI to closest one decimal place
-
Accept BMI values from 12.0-99.9
-
If more than one BMI measure on one day, take last measure of the day, if multiple with the same time stamp then keep the lower BMI value
Baseline definition: The most recent measure (if one exists) in the time period 2 years before or on the index date.
Follow-up definition: Measures that occur after the index date.
Data Source: VDW Vital Signs table
coupled.dbp
Short description: Blood Pressure in mmHg
Description:
-
SBP acceptable value range: 30-240 mmHg
-
DBP acceptable value range: 0-160 mmHg
-
If there is a paired BP measure with SBP in acceptable range and DBP missing, code DBP as 0 mmHg
-
Use only outpatient (no ED, no inpatient) BP measures (treat virtual care as outpatient)
-
If more than one BP measure on one day, take last reading of the day
-
If two readings with same date and time stamp, take reading with lowest SBP
Baseline definition: The most recent measure (if one exists) in the time period 2 years before or on the index date.
Follow-up definition: Measures that occur after the index date.
Data Source: HCSRN Virtual Data Warehouse and VDW Vital Signs table
Notes:
-
For this measure, do NOT dis-aggregate SBP and DBP numbers: take both SBP and DBP from the same reading.
coupled.sbp
Short description: Blood Pressure in mmHg
Description:
-
SBP acceptable value range: 30-240 mmHg
-
DBP acceptable value range: 0-160 mmHg
-
If there is a paired BP measure with SBP in acceptable range and DBP missing, code DBP as 0 mmHg
-
Use only outpatient (no ED, no inpatient) BP measures (treat virtual care as outpatient)
-
If more than one BP measure on one day, take last reading of the day
-
If two readings with same date and time stamp, take reading with lowest SBP
Baseline definition: The most recent measure (if one exists) in the time period 2 years before or on the index date.
Follow-up definition: Measures that occur after the index date.
Data Source: HCSRN Virtual Data Warehouse and VDW Vital Signs table
Notes:
-
For this measure, do NOT dis-aggregate SBP and DBP numbers: take both SBP and DBP from the same reading.
creat
Short description: Creatinine Serum (mg/dl) used to calculate eGFR
Description:
-
Plausible values: 0.1-40 mg/dl
-
Only take outpatient (no ED, no inpatient)
-
If two measures on one day, take lowest measure without regard to time
-
Units: MG/DL or missing for all sites
Baseline definition: The most recent measure (if one exists) in the time period 2 years before or on the index date.
Follow-up definition: Measures that occur after the index date.
Data Source: VDW lab table
Notes: Serum Creatinine will be collinear to a considerable degree with eGFR.
dbp
Short description: Diastolic BP in mmHg
Description:
-
DBP acceptable value range: 0-160 mmHg
-
Use only outpatient (no ED, no inpatient) BP measures (treat virtual care as outpatient)
-
If more than one DBP measure on one day, take lowest DPB reading of the day regardless of time
Baseline definition: The most recent measure (if one exists) in the time period 2 years before or on the index date.
Follow-up definition: Measures that occur after the index date.
Data Source: HCSRN Virtual Data Warehouse and VDW Vital Signs table
fpg
Short description: FPG (Fasting Plasma Glucose) drawn after minimum 8 hours fasting (mg/dl)
Description:
-
Minimum 8 hours fasting
-
Plausible values: 10-1200 mg/dl
-
Only take outpatient (including ER); (no inpatient)
-
If more than one measure on one day, take lowest measure
-
Units: MG/DL for all sites, keep missing for all sites
Baseline definition: The most recent measure (if one exists) in the time period 2 years before or on the index date.
Follow-up definition: Measures that occur after the index date.
Data Source: VDW lab table
gfr_epi_09
Short description: eGFR-2009 (continuous variable, calculated using CKD-EPI 2009 equation)
Description:
-
Plausible values: 0-200 ml/min/1.73m2
-
Only take outpatient (no ER, no inpatient)
-
Sex value other than male or female is treated as female since eGFR is non-defined for non-male/female sex and female results in a lower eGFR value when other terms are held constant
Baseline definition: The most recent measure (if one exists) in the time period 2 years before or on the index date.
Follow-up definition: Measures that occur after the index date.
Data Source: VDW lab table
Procedure: Use CKD-EPI 2009 equation:
https://www.acpjournals.org/doi/10.7326/0003-4819-150-9-200905050-00006?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed#t2-6 Notes: Use this 2009 eGFR variable for confounding adjustment.
hdl
Short description: HDL (high-density lipoprotein) continuous variable (mg/dl)
Description:
-
Acceptable values 5-140 mg/dl
-
Take all measures (inpatient, outpatient, ER)
-
If two measures on one day, take last measure based on time lab drawn
-
If two measures on same day and same time stamp, use highest value
-
Units: MG/DL only
Baseline definition: The most recent measure (if one exists) in the time period 2 years before or on the index date.
Follow-up definition: Measures that occur after the index date.
Data Source: VDW lab table
hgb
Short description: Hemoglobin
Description:
-
Plausible values: 3-30 g/dl
-
Only take outpatient (no ER, no inpatient)
-
If same date and time stamp, take lowest measure
-
If two measures on one day, take last measure
-
Units: G/DL or missing for all sites
Baseline definition: The most recent measure (if one exists) in the time period 2 years before or on the index date.
Follow-up definition: Measures that occur after the index date.
Data Source: VDW lab table
ldl
Short description: LDL (low-density lipoprotein) cholesterol
Description:
-
Acceptable values 20-3000 mg/dl
-
Take all measures (inpatient, outpatient, ER)
-
If two measures on one day, take last LDL measure of the day
-
If two measures on same day and same time stamp, use lowest value
-
Units: MG/DL
-
for LDL_CLC_F: GHS throw out all except MG/DL, HPI keep missings, MG/DL only for other sites
-
for LDL_CLC_NS: MG/DL only for all sites
-
for LDL_DIRECT: GHS use MG/DL only, HFHS & HPI keeping missing & MG/DL
Baseline definition: The most recent measure (if one exists) in the time period 2 years before or on the index date.
Follow-up definition: Measures that occur after the index date.
Data Source: VDW lab table
Notes:
-
Calculated LDL is quantified using the Freidewald equation: TC=LDL+HDL+(TRIG/5). TC, HDL, and TRIG are measured directly, and the equation is solved for LDL. Direct LDL is measured in the lab without using the Freidewald equation.
pcr
Short description: Urinary Protein Creatinine Ratio
Description:
-
Plausible Range: any value >= 0
-
Treat this test as an indicator variable rather than using the actual text value (i.e. either a test occurred on X day/ in X time period or it did not), all non-missing PCR values are set to 0 and still treated as a sporadic variable by LtAt, we then analyze the I.PCR variable created by LtAt which will indicate when a PCR was missing or not (I.PCR=0 means there was a test, 1 means no test)
-
Only take outpatient (no ER, no inpatient)
-
Units: G/GM, MG/G, MG/MG, UN, or missing
Baseline definition: Indicator of a test occuring in the time period 2 years before or on the index date.
Follow-up definition: Measures that occur after the index date.
Data Source: VDW lab table
potassium
Short description: Serum Potassium (K)
Description:
-
Plausible values: 1-10 mg/dl
-
Normal range 3.5-5.5 mg/dl (or mEq/L or mmol/L) inclusive.
-
Only take outpatient (no ER, no inpatient)
-
If two measures on one day, take lowest measure, without regard to time
-
Units: MEQ/L, MMOL/L, or missing for all sites (except remove KPNC, KPSC missings)
Baseline definition: The most recent measure (if one exists) in the time period 2 years before or on the index date.
Follow-up definition: Measures that occur after the index date.
Data Source: VDW lab table
rpg
Short description: RPG (Random Plasma Glucose) drawn after <8 hours or measured without specified number of hours fasting (mg/dl)
Description:
-
Unknown hours fasting, or else less than 8 hours fasting
-
Only take outpatient (including ER); (no inpatient)
-
Plausible values: 10-1200 mg/dl
-
if more than one measure on one day, take lowest measure
-
Units: MG/DL for all, keep missing for all except KPNC & KPSC
Baseline definition: The most recent measure (if one exists) in the time period 2 years before or on the index date.
Follow-up definition: Measures that occur after the index date.
Data Source: VDW lab table
sbp
Short description: Systolic BP in mmHg
Description:
-
SBP acceptable value range: 30-240 mmHg
-
Use only outpatient (no ED, no inpatient) BP measures (treat virtual care as outpatient)
-
If more than one SBP measure on one day, take lowest SBP reading of the day regardless of time
Baseline definition: The most recent measure (if one exists) in the time period 2 years before or on the index date.
Follow-up definition: Measures that occur after the index date.
Data Source: HCSRN Virtual Data Warehouse and VDW Vital Signs table
smoking_status
Short description: Classify patient’s smoking status on index date based on EMR data
Description:
-
Ascertain most recent smoking status on or most recent prior to index date (back to Jan 1st 2009, the earliest date of VDW datapulls), possible values are: Current Smoker, Former Smoker, Passive Smoker, Never Smoker, and Unknown
-
Exception: If and only if value identified is “Former Smoker,” look back at all smoking data for 12 months prior to index date. If any of those values are “Current Smoker,” then classify that patient as a “Current Smoker” on Index Date.
-
For same day-same index-fill records, insitute the following value hierarchy (1:Current Smoker, 2:Former Smoker, 3:Passive Smoker, 4:Never Smoker, and 5:Unknown) and keep the record with the lowest hierarchy value per date for each index-fill.
-
Follow-up measures are smoking status measures that occur after the index date.
sodium
Short description: Serum Sodium (Na)
Description:
-
Plausible values: 90-160 mg/dl
-
Normal range: 135-145 mg/dl (or mEq/L or mmol/L) inclusive
-
Normal range may vary by lab and by various definitions, but are substantively similar to the range proposed here
-
Only take outpatient (no ER, no inpatient)
-
If same date and time stamp, take lowest measure
-
If two measures on one day, take last measure
-
Units: MEQ/L, MMOL/L, remove missing for KPNC, KPSC, keep missing for HPI
Baseline definition: The most recent measure (if one exists) in the time period 2 years before or on the index date.
Follow-up definition: Measures that occur after the index date.
Data Source: VDW lab table
tc
Short description: Total cholesterol (mg/dl)
Description:
-
Acceptable values 80-3000 mg/dl
-
Take all measures (inpatient, outpatient, ER)
-
If two measures on one day, take last measure
-
If two measures on same day and same time stamp, use lowest value
-
Units: MG/DL for all sites, keep missing if in range for all sites
Baseline definition: The most recent measure (if one exists) in the time period 2 years before or on the index date.
Follow-up definition: Measures that occur after the index date.
Data Source: VDW lab table
trig
Short description: Triglycerides (mg/dl)
Description:
-
Accept values 10-4000 mg/dl
-
Take all measures (inpatient, outpatient, ER)
-
If two measures on one day, take last measure
-
If two measures on same day and same time stamp, use lowest value
-
Units: MG/DL, keep missing for HPI and HFHS only
Baseline definition: The most recent measure (if one exists) in the time period 2 years before or on the index date.
Follow-up definition: Measures that occur after the index date.
Data Source: VDW lab table
tsh
Short description: Thyroid Stimulating Hormone
Description:
-
Plausible values: 0-40 mIU/L
-
Normal range 0.4 to 4.0 mIU/L inclusive
-
Can use all tests (inpatient, outpatient, ED)
-
If two measures on one day, take last measure
-
If same date and time stamp, take highest measure
-
Units: MCIU/ML, U[IU]/ML, UIU/ML, or missing for all sites
Baseline definition: The most recent measure (if one exists) in the time period 2 years before or on the index date.
Follow-up definition: Measures that occur after the index date.
Data Source: VDW lab table